Researchers at the University Medical Center (UMC) in Amsterdam have located a rare genetic mutation that appreciably reduces the danger of Alzheimer’s disease and two other forms of dementia.
In addition, it is possible for this gene to increase the chance of a longer life.
This extraordinarily necessary discovering brings new possibilities in the development of a drug for Alzheimer’s disease, but also other forms of dementia that can not be treated for the time being.
Scientists expect that the discovery of this gene responsible for the regulation of the brain cleansing system will lead to a step closer to the drug for Alzheimer’s.
The research team, led through scientific geneticist Hene Holstein at the UMC in Amsterdam, mentioned that over sixteen unique populace companies were covered in the 60 lookup institutes in Europe and North and South America.
Hene Holstein is known for her genetic study about in people older than a hundred years.
In one of the preceding studies, the genetic variant of Ps 72824905 has been introduced about the protection of Alzheimer’s disease, but because this gene is extremely uncommon – only one man of a hundred human beings with European ancestors has this gene – now analyzed facts of 53,000 people from Europe and North America, which has accelerated the wide variety of humans with this gene who participated in the research.
The results of the study are spectacular: people with the gene PC 72824905 have a lower chance of having Alzheimer’s disease, frotomemporal dementia, and dementia with Levi’s bodies (DLT). The influence of this gene on the development of vascular dementia is not included in this research.
Scientists hope that the newly determined gene has a protective role in the development of Parkinson’s disease, more than one sclerosis, and amyotrophic lateral sclerosis (ALS), however this is now not the case.
The function of the gene RS 72824905 is related to the longevity.
People with this gene older than 90 years old, whose statistics are analyzed, live on average for a 12 months longer, however due to the fact that the analyzed group is tremendously small, it is not possible to eliminate coincidence.
However, the only group of 100 years olds, from the same research, are twice as likely to own this gene.
One of the carriers of the gene, a healthy woman of 104 years, in addition to the newly discovered gene, even carries two genes that in other patients cause extremely rapid production of harmful proteins in the brain cells.
Carriers of these two genes often at younger age suffer from dementia, while centenarians rarely carry those genes.
However, the gene PC 72824905 is probably to have a shielding role in the manufacturing of this protein: in patients who have memory troubles however are carriers of this gene, the process of producing harmful proteins in the brain cells is significantly slower.
That’s why scientists believe that with the aid of detecting the way this gene works, it will be notably nearer to the Alzheimer’s medicine.
In the forms of dementia that encompassed the research, brain cells die out due to the production of harmful proteins in them.
Although it is no longer but recognized how it comes to this, scientists believe that a massive phase is prompted via the fact that the Genius drainage device has been functioning for years.